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What the FDA labels say about taking them together

Ascorbic acid and lincomycin

Ascorbic acid's FDA label of May 29, 2026 names lincomycin in its drug interactions section; the lincomycin label PlainMeds reads does not name ascorbic acid. The ascorbic acid label: “DRUG INTERACTIONS ​Antibiotics:​ Ascorbic acid may decrease the activities of erythromycin, kanamycin, streptomycin, doxycycline, and lincomycin.”

Check it at the source: the ascorbic acid FDA label on DailyMed (effective May 29, 2026, McGuff Pharmaceuticals, Inc.); the lincomycin FDA label on DailyMed (effective March 10, 2025, Pharmacia & Upjohn Company LLC).

What does the ascorbic acid label say about lincomycin?

Ascorbic acid label, drug interactions

DRUG INTERACTIONS ​Antibiotics:​ Ascorbic acid may decrease the activities of erythromycin, kanamycin, streptomycin, doxycycline, and lincomycin.

Source: FDA drug label (Ascor), McGuff Pharmaceuticals, Inc., effective May 29, 2026 (SPL set 388aad52-fc01-4784-9791-1dbc80c69306), via openFDA; the full label on DailyMed

What does the lincomycin label say about ascorbic acid?

Lincomycin's label (effective March 10, 2025) does not name ascorbic acid in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Lincocin), NDA050317 (Pfizer), as published by Pharmacia & Upjohn Company LLC, effective March 10, 2025 (SPL set c01906fa-2c73-4c13-9765-2fd06628d263), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

4Ascorbic acid generic labelers
8Lincomycin generic labelers
Ascorbic acidLincomycin
Labeled forn/aBacterial infections
Boxed warningNoYes
Pharmacy cost (NADAC)n/an/a
Shortage nowNo current entryA presentation being discontinued

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?