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What the FDA labels say about taking them together

Ascorbic acid and fluphenazine

Ascorbic acid's FDA label of May 29, 2026 names fluphenazine in its drug interactions section; the fluphenazine label PlainMeds reads does not name ascorbic acid. The ascorbic acid label: “It has been reported that concurrent administration of ascorbic acid and fluphenazine has resulted in decreased fluphenazine plasma concentrations.”

Check it at the source: the ascorbic acid FDA label on DailyMed (effective May 29, 2026, McGuff Pharmaceuticals, Inc.); the fluphenazine FDA label on DailyMed (effective April 14, 2026, Amneal Pharmaceuticals NY LLC).

What does the ascorbic acid label say about fluphenazine?

Ascorbic acid label, drug interactions

It has been reported that concurrent administration of ascorbic acid and fluphenazine has resulted in decreased fluphenazine plasma concentrations.

Source: FDA drug label (Ascor), McGuff Pharmaceuticals, Inc., effective May 29, 2026 (SPL set 388aad52-fc01-4784-9791-1dbc80c69306), via openFDA; the full label on DailyMed

What does the fluphenazine label say about ascorbic acid?

Fluphenazine's label (effective April 14, 2026) does not name ascorbic acid in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (fluphenazine hydrochloride), Amneal Pharmaceuticals NY LLC, effective April 14, 2026 (SPL set 5b443b30-5682-4cf3-9ed0-716efddbc865), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

4Ascorbic acid generic labelers
36Fluphenazine generic labelers
Ascorbic acidFluphenazine
Labeled forn/an/a
Boxed warningNoYes
Pharmacy cost (NADAC)n/a$0.431 per tablet 10 mg tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?