What the FDA labels say about taking them together
Ascorbic acid and ethinyl estradiol/ferrous fumarate/norethindrone
Ethinyl estradiol/ferrous fumarate/norethindrone's FDA label (Lo Loestrin Fe) of March 7, 2025 names ascorbic acid in its drug interactions section; the ascorbic acid label PlainMeds reads does not name ethinyl estradiol/ferrous fumarate/norethindrone. The ethinyl estradiol/ferrous fumarate/norethindrone label: “Ascorbic acid and acetaminophen may increase plasma ethinyl estradiol levels, possibly by inhibition of conjugation.”
Check it at the source: the ascorbic acid FDA label on DailyMed (effective May 29, 2026, McGuff Pharmaceuticals, Inc.); the ethinyl estradiol/ferrous fumarate/norethindrone FDA label on DailyMed (effective May 21, 2026, PD-Rx Pharmaceuticals, Inc.).
What does the ascorbic acid label say about ethinyl estradiol/ferrous fumarate/norethindrone?
Ascorbic acid's label (effective May 29, 2026) does not name ethinyl estradiol/ferrous fumarate/norethindrone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ascor), McGuff Pharmaceuticals, Inc., effective May 29, 2026 (SPL set 388aad52-fc01-4784-9791-1dbc80c69306), via openFDA; the full label on DailyMed
What does the ethinyl estradiol/ferrous fumarate/norethindrone label say about ascorbic acid?
Lo Loestrin Fe label (Allergan, Inc., March 7, 2025), drug interactionsAscorbic acid and acetaminophen may increase plasma ethinyl estradiol levels, possibly by inhibition of conjugation.
Source: FDA drug label (Lo Loestrin Fe, NDA022501), Allergan, Inc., effective March 7, 2025 (SPL set c33072cf-625d-4b4a-981e-ec049c5d78aa), via openFDA
Source: FDA drug label (Taytulla, NDA204426), Allergan, Inc., effective October 25, 2024 (SPL set 2fa8e8dc-f7b0-429a-b554-0e3c4291c92c), via openFDA
Source: FDA drug label (Junel Fe 28 Day), ANDA076081 (Barr), as published by PD-Rx Pharmaceuticals, Inc., effective May 21, 2026 (SPL set 93a2f8c9-3550-42ec-8f76-3ac9badf4bb2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ascorbic acid | Ethinyl estradiol/ferrous fumarate/norethindrone | |
|---|---|---|
| Labeled for | n/a | Birth control, Acne |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.142 per tablet 1.5-30 tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once