What the FDA labels say about taking them together
Artemether/lumefantrine and quinidine
Artemether/lumefantrine's FDA label of March 26, 2026 names quinidine in its warnings and precautions section; the quinidine label PlainMeds reads does not name artemether/lumefantrine. The artemether/lumefantrine label: “… option, due to limited safety data. QT prolonging drugs, including quinine and quinidine, should be used cautiously following Coartem Tablets. …”
Check it at the source: the artemether/lumefantrine FDA label on DailyMed (effective March 26, 2026, Novartis Pharmaceuticals Corporation); the quinidine FDA label on DailyMed (effective February 1, 2018, Sun Pharmaceutical Industries, Inc.).
What does the artemether/lumefantrine label say about quinidine?
Artemether/lumefantrine label, warnings and precautionsWARNINGS AND PRECAUTIONS Avoid use in patients with known QT prolongation, those with hypokalemia or hypomagnesemia, and those taking other drugs that prolong the QT interval. ( 5.1 , 12.6 ) Halofantrine and Coartem Tablets should not be administered within one month of each other due to potential additive effects on the QT interval. ( 5.1 , 5.2 , 12.3 ) Antimalarials should not be given concomitantly, unless there is no other treatment option, due to limited safety data. ( 5.2 ) QT prolonging drugs, including quinine and quinidine, should be used cautiously following Coartem Tablets. …
Source: FDA drug label (COARTEM), Novartis Pharmaceuticals Corporation, effective March 26, 2026 (SPL set 7866ec19-dfac-47d4-a53f-511a12643cbf), via openFDA; the full label on DailyMed
What does the quinidine label say about artemether/lumefantrine?
Quinidine's label (effective February 1, 2018) does not name artemether/lumefantrine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Quinidine Gluconate), Sun Pharmaceutical Industries, Inc., effective February 1, 2018 (SPL set 5023f053-fcc4-4c2c-aa59-9ec198ad185e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Artemether/lumefantrine | Quinidine | |
|---|---|---|
| Labeled for | n/a | Atrial fibrillation |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $5.36 per tablet Coartem tablets | $4.92 per tablet 324 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once