What the FDA labels say about taking them together
Artemether/lumefantrine and levonorgestrel
Artemether/lumefantrine's FDA label of March 26, 2026 names levonorgestrel in its drug interactions section; the levonorgestrel labels PlainMeds reads (4) do not name artemether/lumefantrine.
Check it at the source: the artemether/lumefantrine FDA label on DailyMed (effective March 26, 2026, Novartis Pharmaceuticals Corporation); the levonorgestrel FDA label on DailyMed (effective January 31, 2023, Foundation Consumer Healthcare LLC).
What does the artemether/lumefantrine label say about levonorgestrel?
Artemether/lumefantrine label, drug interactionsIn vitro, the metabolism of ethinyl estradiol and levonorgestrel was not induced by artemether, DHA, or lumefantrine.
Source: FDA drug label (COARTEM), Novartis Pharmaceuticals Corporation, effective March 26, 2026 (SPL set 7866ec19-dfac-47d4-a53f-511a12643cbf), via openFDA; the full label on DailyMed
What does the levonorgestrel label say about artemether/lumefantrine?
Levonorgestrel's label (effective January 31, 2023) and its 3 other brand-application labels do not name artemether/lumefantrine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Plan B One-Step), Foundation Consumer Healthcare LLC, effective January 31, 2023 (SPL set 6ce6b40e-14ac-47bd-a648-ddf9e452e559), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Artemether/lumefantrine | Levonorgestrel | |
|---|---|---|
| Labeled for | n/a | Birth control |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $5.36 per tablet Coartem tablets | $6.33 per tablet 1.5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once