What the FDA labels say about taking them together
Artemether/lumefantrine and efavirenz
Efavirenz's FDA label of March 31, 2024 names artemether/lumefantrine in its drug interactions section; the artemether/lumefantrine label PlainMeds reads does not name efavirenz. The efavirenz label: “Antimalarials: Artemether/lumefantrine Atovaquone/ proguanil ↓ artemether * ↓ dihydroartemisinin * ↓ lumefantrine * ↓ atovaquone ↓ proguanil Consider alternatives to artemether/ lumefantrine because of the risk of QT …”
Check it at the source: the artemether/lumefantrine FDA label on DailyMed (effective March 26, 2026, Novartis Pharmaceuticals Corporation); the efavirenz FDA label on DailyMed (effective March 31, 2024, Cipla USA Inc.).
What does the artemether/lumefantrine label say about efavirenz?
Artemether/lumefantrine's label (effective March 26, 2026) does not name efavirenz in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (COARTEM), Novartis Pharmaceuticals Corporation, effective March 26, 2026 (SPL set 7866ec19-dfac-47d4-a53f-511a12643cbf), via openFDA; the full label on DailyMed
What does the efavirenz label say about artemether/lumefantrine?
Efavirenz label, drug interactionsAntimalarials: Artemether/lumefantrine Atovaquone/ proguanil ↓ artemether * ↓ dihydroartemisinin * ↓ lumefantrine * ↓ atovaquone ↓ proguanil Consider alternatives to artemether/ lumefantrine because of the risk of QT interval prolongation.
Source: FDA drug label (Efavirenz), Cipla USA Inc., effective March 31, 2024 (SPL set 92603fa5-7a2c-4bfb-9a70-aadb4fba952c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Artemether/lumefantrine | Efavirenz | |
|---|---|---|
| Labeled for | n/a | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $5.36 per tablet Coartem tablets | $1.28 per tablet 600 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once