What the FDA labels say about taking them together
Artemether/lumefantrine and cobicistat, darunavir, emtricitabine and tenofovir alafenamide
Cobicistat, darunavir, emtricitabine and tenofovir alafenamide's FDA label of April 17, 2026 names artemether/lumefantrine in its drug interactions section; the artemether/lumefantrine label PlainMeds reads does not name cobicistat, darunavir, emtricitabine and tenofovir alafenamide. The cobicistat, darunavir, emtricitabine and tenofovir alafenamide label: “Antimalarial: artemether/lumefantrine artemether: effect unknown lumefantrine: effect unknown Monitor for a potential decrease of antimalarial efficacy or potential QT prolongation.”
Check it at the source: the artemether/lumefantrine FDA label on DailyMed (effective March 26, 2026, Novartis Pharmaceuticals Corporation); the cobicistat, darunavir, emtricitabine and tenofovir alafenamide FDA label on DailyMed (effective April 17, 2026, Janssen Products LP).
What does the artemether/lumefantrine label say about cobicistat, darunavir, emtricitabine and tenofovir alafenamide?
Artemether/lumefantrine's label (effective March 26, 2026) does not name cobicistat, darunavir, emtricitabine and tenofovir alafenamide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (COARTEM), Novartis Pharmaceuticals Corporation, effective March 26, 2026 (SPL set 7866ec19-dfac-47d4-a53f-511a12643cbf), via openFDA; the full label on DailyMed
What does the cobicistat, darunavir, emtricitabine and tenofovir alafenamide label say about artemether/lumefantrine?
Cobicistat, darunavir, emtricitabine and tenofovir alafenamide label, drug interactionsAntimalarial: artemether/lumefantrine artemether: effect unknown lumefantrine: effect unknown Monitor for a potential decrease of antimalarial efficacy or potential QT prolongation.
Source: FDA drug label (Symtuza), Janssen Products LP, effective April 17, 2026 (SPL set 85a17d00-6b7c-41ea-a6b3-5ad924820dab), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Artemether/lumefantrine | Cobicistat, darunavir, emtricitabine and tenofovir alafenamide | |
|---|---|---|
| Labeled for | n/a | HIV |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $5.36 per tablet Coartem tablets | $152.87 per tablet 800-150-200-10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once