What the FDA labels say about taking them together
Armodafinil and modafinil
Armodafinil's FDA label of September 2, 2025 names modafinil in its contraindications section, and modafinil's label names armodafinil too. The armodafinil label: “CONTRAINDICATIONS NUVIGIL is contraindicated in patients with known hypersensitivity to modafinil or armodafinil or its inactive ingredients.”
Check it at the source: the armodafinil FDA label on DailyMed (effective September 2, 2025, Golden State Medical Supply, Inc.); the modafinil FDA label on DailyMed (effective October 16, 2025, Golden State Medical Supply, Inc.).
What does the armodafinil label say about modafinil?
Armodafinil label, contraindicationsCONTRAINDICATIONS NUVIGIL is contraindicated in patients with known hypersensitivity to modafinil or armodafinil or its inactive ingredients [see Warnings and Precautions ( 5.1 , 5.2 , 5.3 )].
Armodafinil label, warnings and precautionsThere are no factors, including duration of therapy, that are known to predict the risk of occurrence or the severity of rash associated with modafinil or NUVIGIL.
Source: FDA drug label (Nuvigil), NDA021875 (Nuvo Pharms), as published by Golden State Medical Supply, Inc., effective September 2, 2025 (SPL set 3dd49302-f757-d945-e063-6294a90afcba), via openFDA; the full label on DailyMed
What does the modafinil label say about armodafinil?
Modafinil label, contraindicationsCONTRAINDICATIONS PROVIGIL is contraindicated in patients with known hypersensitivity to modafinil or armodafinil or its inactive ingredients [see Warnings and Precautions ( 5.1 , 5.2 , 5.3 )].
Modafinil label, warnings and precautionsAngioedema and hypersensitivity (with rash, dysphagia, and bronchospasm), were observed in patients treated with armodafinil, the R enantiomer of modafinil (which is the racemic mixture).
Source: FDA drug label (Provigil), NDA020717 (Nuvo Pharms), as published by Golden State Medical Supply, Inc., effective October 16, 2025 (SPL set 3b8d1c32-dac9-50e6-e063-6394a90aa5a5), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Armodafinil | Modafinil | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.788 per tablet 150 mg tablet | $0.344 per tablet 200 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once