What the FDA labels say about taking them together
Armodafinil and midazolam
Armodafinil's FDA label of September 2, 2025 names midazolam in its drug interactions section; the midazolam labels PlainMeds reads (4) do not name armodafinil. The armodafinil label: “DRUG INTERACTIONS Effects of NUVIGIL on CYP3A4/5 Substrates The clearance of drugs that are substrates for CYP3A4/5 may be increased by NUVIGIL via induction of metabolic enzymes, which results in lower systemic …”
Check it at the source: the armodafinil FDA label on DailyMed (effective September 2, 2025, Golden State Medical Supply, Inc.); the midazolam FDA label on DailyMed (effective January 1, 2024, Fresenius Kabi USA, LLC).
What does the armodafinil label say about midazolam?
Armodafinil label, drug interactionsDRUG INTERACTIONS Effects of NUVIGIL on CYP3A4/5 Substrates The clearance of drugs that are substrates for CYP3A4/5 (e.g., steroidal contraceptives, cyclosporine, midazolam, and triazolam) may be increased by NUVIGIL via induction of metabolic enzymes, which results in lower systemic exposure.
Source: FDA drug label (Nuvigil), NDA021875 (Nuvo Pharms), as published by Golden State Medical Supply, Inc., effective September 2, 2025 (SPL set 3dd49302-f757-d945-e063-6294a90afcba), via openFDA; the full label on DailyMed
What does the midazolam label say about armodafinil?
Midazolam's label (effective January 1, 2024) and its 3 other brand-application labels do not name armodafinil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Midazolam), Fresenius Kabi USA, LLC, effective January 1, 2024 (SPL set 1cc9ba6e-fa1b-405e-9de8-720c567b2a73), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Armodafinil | Midazolam | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.788 per tablet 150 mg tablet | $0.233 per mL 2 mg/2 mL vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once