What the FDA labels say about taking them together
Armodafinil and esketamine
Esketamine's FDA label of March 31, 2026 names armodafinil in its drug interactions section; the armodafinil label PlainMeds reads does not name esketamine. The esketamine label: “Concomitant use with psychostimulants may increase blood pressure.”
Check it at the source: the armodafinil FDA label on DailyMed (effective September 2, 2025, Golden State Medical Supply, Inc.); the esketamine FDA label on DailyMed (effective March 31, 2026, Janssen Pharmaceuticals, Inc.).
What does the armodafinil label say about esketamine?
Armodafinil's label (effective September 2, 2025) does not name esketamine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Nuvigil), NDA021875 (Nuvo Pharms), as published by Golden State Medical Supply, Inc., effective September 2, 2025 (SPL set 3dd49302-f757-d945-e063-6294a90afcba), via openFDA; the full label on DailyMed
What does the esketamine label say about armodafinil?
Esketamine label, drug interactionsConcomitant use with psychostimulants (e.g., amphetamines, methylphenidate, modafinil, armodafinil) may increase blood pressure [see Warnings and Precautions (5.7) ].
Source: FDA drug label (Spravato), Janssen Pharmaceuticals, Inc., effective March 31, 2026 (SPL set d81a6a79-a74a-44b7-822c-0dfa3036eaed), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Armodafinil | Esketamine | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.788 per tablet 150 mg tablet | $429.98 per unit 84 mg dose pack |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once