What the FDA labels say about taking them together
Aripiprazole lauroxil and lorazepam
Aripiprazole lauroxil's FDA label of January 28, 2025 names lorazepam in its drug interactions section; lorazepam's label does not name aripiprazole lauroxil itself but warns about its class (Atypical antipsychotics). The aripiprazole lauroxil label: “The intensity of sedation was greater with the combination of oral aripiprazole and lorazepam as compared to that observed with aripiprazole alone. …”
Check it at the source: the aripiprazole lauroxil FDA label on DailyMed (effective January 28, 2025, Alkermes, Inc.); the lorazepam FDA label on DailyMed (effective July 9, 2025, Bausch Health US LLC).
What does the aripiprazole lauroxil label say about lorazepam?
Aripiprazole lauroxil label, drug interactionsBenzodiazepines Clinical Impact: The intensity of sedation was greater with the combination of oral aripiprazole and lorazepam as compared to that observed with aripiprazole alone. The orthostatic hypotension observed was greater with the combination as compared to that observed with lorazepam alone. Intervention: Monitor sedation and blood pressure. Adjust dose accordingly. Example: lorazepam
Source: FDA drug label (ARISTADA), Alkermes, Inc., effective January 28, 2025 (SPL set 17a8d11b-73b0-4833-a0b4-cf1ef85edefb), via openFDA; the full label on DailyMed
What does the lorazepam label say about aripiprazole lauroxil?
Lorazepam's label does not name aripiprazole lauroxil itself; it warns about its class (Atypical antipsychotics):
Lorazepam label, drug interactionsThe benzodiazepines, including Ativan (lorazepam), produce increased CNS-depressant effects when administered with other CNS depressants such as alcohol, barbiturates, antipsychotics, sedative/hypnotics, anxiolytics, antidepressants, narcotic analgesics, sedative antihistamines, anticonvulsants, and anesthetics.
Source: FDA drug label (Ativan), Bausch Health US LLC, effective July 9, 2025 (SPL set 89057c93-8155-4040-acec-64e877bd2b4c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aripiprazole lauroxil | Lorazepam | |
|---|---|---|
| Labeled for | Schizophrenia | Anxiety |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $993.60 per mL 1,064 mg/3.9 mL syringe | $0.0344 per tablet 0.5 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once