What the FDA labels say about taking them together
Aripiprazole lauroxil and lisinopril
Aripiprazole lauroxil's FDA label of January 28, 2025 names lisinopril in its drug interactions section; the lisinopril labels PlainMeds reads (2) do not name aripiprazole lauroxil.
Check it at the source: the aripiprazole lauroxil FDA label on DailyMed (effective January 28, 2025, Alkermes, Inc.); the lisinopril FDA label on DailyMed (effective January 2, 2025, Upsher-Smith Laboratories, LLC).
What does the aripiprazole lauroxil label say about lisinopril?
Aripiprazole lauroxil label, drug interactionsClinical Impact: Due to its alpha adrenergic antagonism, aripiprazole has the potential to enhance the effect of certain antihypertensive agents. Intervention: Monitor blood pressure and adjust dose accordingly [see Warnings and Precautions ( 5.8 )]. Examples: carvedilol, lisinopril, prazosin Benzodiazepines
Aristada Initio label (Alkermes, Inc., January 28, 2025), drug interactionsClinical Impact: Due to its alpha adrenergic antagonism, aripiprazole has the potential to enhance the effect of certain antihypertensive agents. Intervention: Avoid concomitant use of ARISTADA INITIO with antihypertensive drugs because the dosage of ARISTADA INITIO cannot be modified [see Warnings and Precautions ( 5.8 )]. Examples: carvedilol, lisinopril, prazosin Benzodiazepines
Source: FDA drug label (Aristada Initio, NDA209830), Alkermes, Inc., effective January 28, 2025 (SPL set b18fdfd9-31cd-4a2f-9f1c-ebc70d7a9403), via openFDA
Source: FDA drug label (ARISTADA), Alkermes, Inc., effective January 28, 2025 (SPL set 17a8d11b-73b0-4833-a0b4-cf1ef85edefb), via openFDA; the full label on DailyMed
What does the lisinopril label say about aripiprazole lauroxil?
Lisinopril's label (effective January 2, 2025) and its 1 other brand-application label do not name aripiprazole lauroxil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Zestril), NDA019777 (Twi Pharms), as published by Upsher-Smith Laboratories, LLC, effective January 2, 2025 (SPL set 838c2d78-d2d8-4981-9ec9-e50ef9e1a5d8), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aripiprazole lauroxil | Lisinopril | |
|---|---|---|
| Labeled for | Schizophrenia | High blood pressure, Heart attack and coronary artery disease, Heart failure |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $993.60 per mL 1,064 mg/3.9 mL syringe | $0.0254 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once