What the FDA labels say about taking them together
Aripiprazole and rifampin
Aripiprazole's FDA label of January 29, 2025 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name aripiprazole. The aripiprazole label: “Increase the ABILIFY dosage when administered concomitantly with a strong CYP3A4 inducer.”
Check it at the source: the aripiprazole FDA label on DailyMed (effective January 29, 2025, Otsuka America Pharmaceutical, Inc.); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the aripiprazole label say about rifampin?
Aripiprazole label, drug interactionsConcomitant Drug Name or Drug Class: Strong CYP3A4 Inducers (e.g., carbamazepine, rifampin); Clinical Rationale: Concomitant use of ABILIFY and carbamazepine decreased the exposure of aripiprazole compared to the use of ABILIFY alone [see ].; Clinical Recommendation: Increase the ABILIFY dosage when administered concomitantly with a strong CYP3A4 inducer [see ].
Source: FDA drug label (ABILIFY), Otsuka America Pharmaceutical, Inc., effective January 29, 2025 (SPL set c040bd1d-45b7-49f2-93ea-aed7220b30ac), via openFDA; the full label on DailyMed
What does the rifampin label say about aripiprazole?
Rifampin's label (effective February 11, 2026) does not name aripiprazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aripiprazole | Rifampin | |
|---|---|---|
| Labeled for | Depression, Bipolar disorder, Schizophrenia | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.110 per tablet 5 mg tablet | $0.679 per capsule 300 mg capsule |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once