What the FDA labels say about taking them together
Aripiprazole and lorazepam
Aripiprazole's FDA label of January 29, 2025 names lorazepam in its drug interactions section; lorazepam's label does not name aripiprazole itself but warns about its class (Atypical antipsychotics). The aripiprazole label: “The orthostatic hypotension observed was greater with the combination as compared to that observed with lorazepam alone. Monitor sedation and blood pressure.”
Check it at the source: the aripiprazole FDA label on DailyMed (effective January 29, 2025, Otsuka America Pharmaceutical, Inc.); the lorazepam FDA label on DailyMed (effective July 9, 2025, Bausch Health US LLC).
What does the aripiprazole label say about lorazepam?
Aripiprazole label, drug interactionsThe orthostatic hypotension observed was greater with the combination as compared to that observed with lorazepam alone [see Warnings and Precautions (5.8) ]. Monitor sedation and blood pressure.
Opipza label (Carwin Pharmaceutical Associates, LLC, January 30, 2025), drug interactionsClinical Rationale; The intensity of sedation was greater with the combination of oral aripiprazole and lorazepam as compared to that observed with aripiprazole alone. The orthostatic hypotension observed was greater with the combination as compared to that observed with lorazepam alone [see ].
Source: FDA drug label (Abilify Maintena, NDA202971), Otsuka America Pharmaceutical, Inc., effective March 24, 2026 (SPL set ee49f3b1-1650-47ff-9fb1-ea53fe0b92b6), via openFDA
Source: FDA drug label (Opipza, NDA216655), Carwin Pharmaceutical Associates, LLC, effective January 30, 2025 (SPL set b47ede68-8942-4432-af7e-57afc14b2ba4), via openFDA
Source: FDA drug label (ABILIFY), Otsuka America Pharmaceutical, Inc., effective January 29, 2025 (SPL set c040bd1d-45b7-49f2-93ea-aed7220b30ac), via openFDA; the full label on DailyMed
What does the lorazepam label say about aripiprazole?
Lorazepam's label does not name aripiprazole itself; it warns about its class (Atypical antipsychotics):
Lorazepam label, drug interactionsThe benzodiazepines, including Ativan (lorazepam), produce increased CNS-depressant effects when administered with other CNS depressants such as alcohol, barbiturates, antipsychotics, sedative/hypnotics, anxiolytics, antidepressants, narcotic analgesics, sedative antihistamines, anticonvulsants, and anesthetics.
Source: FDA drug label (Ativan), Bausch Health US LLC, effective July 9, 2025 (SPL set 89057c93-8155-4040-acec-64e877bd2b4c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aripiprazole | Lorazepam | |
|---|---|---|
| Labeled for | Depression, Bipolar disorder, Schizophrenia | Anxiety |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.110 per tablet 5 mg tablet | $0.0344 per tablet 0.5 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once