What the FDA labels say about taking them together
Aripiprazole and lamotrigine
Aripiprazole's FDA label of January 29, 2025 names lamotrigine in its drug interactions section; the lamotrigine labels PlainMeds reads (3) do not name aripiprazole. The aripiprazole label: “Additionally, no dosage adjustment is necessary for valproate, lithium, lamotrigine, lorazepam, or sertraline when coadministered with ABILIFY.”
Check it at the source: the aripiprazole FDA label on DailyMed (effective January 29, 2025, Otsuka America Pharmaceutical, Inc.); the lamotrigine FDA label on DailyMed (effective October 10, 2025).
What does the aripiprazole label say about lamotrigine?
Aripiprazole label, drug interactionsAdditionally, no dosage adjustment is necessary for valproate, lithium, lamotrigine, lorazepam, or sertraline when coadministered with ABILIFY [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (Abilify Maintena, NDA202971), Otsuka America Pharmaceutical, Inc., effective March 24, 2026 (SPL set ee49f3b1-1650-47ff-9fb1-ea53fe0b92b6), via openFDA
Source: FDA drug label (Opipza, NDA216655), Carwin Pharmaceutical Associates, LLC, effective January 30, 2025 (SPL set b47ede68-8942-4432-af7e-57afc14b2ba4), via openFDA
Source: FDA drug label (Abilify Asimtufii, NDA217006), Otsuka America Pharmaceutical, Inc, effective April 4, 2025 (SPL set da4c07fd-1130-4341-bb44-63acfa4162be), via openFDA
Source: FDA drug label (ABILIFY), Otsuka America Pharmaceutical, Inc., effective January 29, 2025 (SPL set c040bd1d-45b7-49f2-93ea-aed7220b30ac), via openFDA; the full label on DailyMed
What does the lamotrigine label say about aripiprazole?
Lamotrigine's label (effective October 10, 2025) and its 2 other brand-application labels do not name aripiprazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LAMICTAL), GlaxoSmithKline LLC, effective October 10, 2025 (SPL set d7e3572d-56fe-4727-2bb4-013ccca22678), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aripiprazole | Lamotrigine | |
|---|---|---|
| Labeled for | Depression, Bipolar disorder, Schizophrenia | Seizures and epilepsy, Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.110 per tablet 5 mg tablet | $0.0268 per tablet 25 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once