What the FDA labels say about taking them together
Argatroban and heparin
Argatroban's FDA label of May 3, 2026 names heparin in its drug interactions section; heparin's label does not name argatroban itself but warns about its class (anti-coagulants). The argatroban label: “DRUG INTERACTIONS Heparin: Allow sufficient time for heparin's effect on aPTT to decrease before initiating Argatroban in Sodium Chloride Injection therapy Warfarin:”
Check it at the source: the argatroban FDA label on DailyMed (effective May 3, 2026, Hikma Pharmaceuticals USA Inc.); the heparin FDA label on DailyMed (effective November 28, 2025, Fresenius Kabi USA, LLC).
What does the argatroban label say about heparin?
Argatroban label, drug interactionsDRUG INTERACTIONS Heparin: Allow sufficient time for heparin’s effect on activated partial thromboplastin time (aPTT) to decrease before initiating Argatroban Injection therapy.
Argatroban label (Accord Healthcare Inc., May 21, 2026), drug interactionsDRUG INTERACTIONS Heparin: Allow sufficient time for heparin's effect on aPTT to decrease before initiating Argatroban in Sodium Chloride Injection therapy ( 7.1 ) Warfarin:
Argatroban label (Eugia US LLC, August 3, 2023), drug interactionsDRUG INTERACTIONS 7.1 Heparin If Argatroban in sodium chloride injection is to be initiated after cessation of heparin therapy, allow sufficient time for heparin’s effect on the aPTT to decrease prior to initiation of Argatroban in sodium chloride injection therapy.
Source: FDA drug label (Argatroban, NDA212035), Accord Healthcare Inc., effective May 21, 2026 (SPL set 46cdf9e6-839c-49c8-9ee1-c30cfdd9368d), via openFDA
Source: FDA drug label (Argatroban, NDA209552), Eugia US LLC, effective August 3, 2023 (SPL set d9b975bd-e3f4-466e-96ca-7bef7899506d), via openFDA
Source: FDA drug label (Argatroban, NDA022485), Plano Pharmaceuticals Inc., effective September 9, 2026 (SPL set 514ad15b-d060-9d65-e063-6294a90a6188), via openFDA
Source: FDA drug label (Argatroban), Hikma Pharmaceuticals USA Inc., effective May 3, 2026 (SPL set 0cdf3f67-5bf3-4d58-b330-03febdc652bf), via openFDA; the full label on DailyMed
What does the heparin label say about argatroban?
Heparin's label does not name argatroban itself; it warns about its class (anti-coagulants):
Heparin label, warnings and precautionsAdrenal hemorrhage (with resultant acute adrenal insufficiency), ovarian hemorrhage, and retroperitoneal hemorrhage have occurred during anticoagulant therapy with heparin [see Adverse Reactions ( 6.1 )].
Heparin label, drug interactionsTo reduce the risk of bleeding, a reduction in the dose of antiplatelet agent or heparin is recommended. Other Interactions Digitalis, tetracyclines, nicotine or antihistamines may partially counteract the anticoagulant action of heparin sodium.
Source: FDA drug label (Heparin Sodium), Fresenius Kabi USA, LLC, effective November 28, 2025 (SPL set d55b4a63-0c04-4874-b74f-9e9b9e8b008c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Argatroban | Heparin | |
|---|---|---|
| Labeled for | n/a | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $1.18 per mL 5,000 unit/mL vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once