What the FDA labels say about taking them together
Aprepitant and rifampin
Aprepitant's FDA label of July 5, 2024 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name aprepitant. The aprepitant label: “Use of EMEND with strong CYP3A4 inducers (e.g., rifampin) may result in a reduction in aprepitant plasma concentrations and decreased efficacy of EMEND.”
Check it at the source: the aprepitant FDA label on DailyMed (effective July 5, 2024, Merck Sharp & Dohme LLC); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the aprepitant label say about rifampin?
Aprepitant label, drug interactionsExamples; rifampin, carbamazepine, phenytoin
Aprepitant label, warnings and precautionsUse of EMEND with strong CYP3A4 inducers (e.g., rifampin) may result in a reduction in aprepitant plasma concentrations and decreased efficacy of EMEND.
Source: FDA drug label (Cinvanti, NDA209296), Heron Therapeutics, Inc., effective April 1, 2026 (SPL set 4c218d3a-a508-4abc-9ed8-a6e8e191d1b4), via openFDA
Source: FDA drug label (Aponvie, NDA216457), Heron Therapeutics, Inc., effective April 1, 2026 (SPL set d1b111eb-659a-496b-a86a-8f0fa370f147), via openFDA
Source: FDA drug label (EMEND), NDA021549 (Msd), as published by Merck Sharp & Dohme LLC, effective July 5, 2024 (SPL set 696f9e80-9cae-403b-de9e-078343ce4713), via openFDA; the full label on DailyMed
What does the rifampin label say about aprepitant?
Rifampin's label (effective February 11, 2026) does not name aprepitant in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aprepitant | Rifampin | |
|---|---|---|
| Labeled for | Nausea and vomiting | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $46.42 per capsule 40 mg capsule | $0.679 per capsule 300 mg capsule |
| Shortage now | A presentation being discontinued | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once