What the FDA labels say about taking them together
Aprepitant and ethinyl estradiol/ferrous fumarate/levonorgestrel
Ethinyl estradiol/ferrous fumarate/levonorgestrel's FDA label of October 18, 2024 names aprepitant in its drug interactions section; the aprepitant labels PlainMeds reads (3) do not name ethinyl estradiol/ferrous fumarate/levonorgestrel. The ethinyl estradiol/ferrous fumarate/levonorgestrel label: “… griseofulvin, oxcarbazepine, rifampicin, topiramate, rifabutin, rufinamide, aprepitant, and products containing St. John’s wort.”
Check it at the source: the aprepitant FDA label on DailyMed (effective July 5, 2024, Merck Sharp & Dohme LLC); the ethinyl estradiol/ferrous fumarate/levonorgestrel FDA label on DailyMed (effective October 18, 2024, Xiromed, LLC).
What does the aprepitant label say about ethinyl estradiol/ferrous fumarate/levonorgestrel?
Aprepitant's label (effective July 5, 2024) and its 2 other brand-application labels do not name ethinyl estradiol/ferrous fumarate/levonorgestrel in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (EMEND), NDA021549 (Msd), as published by Merck Sharp & Dohme LLC, effective July 5, 2024 (SPL set 696f9e80-9cae-403b-de9e-078343ce4713), via openFDA; the full label on DailyMed
What does the ethinyl estradiol/ferrous fumarate/levonorgestrel label say about aprepitant?
Ethinyl estradiol/ferrous fumarate/levonorgestrel label, drug interactionsSome drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampicin, topiramate, rifabutin, rufinamide, aprepitant, and products containing St. John’s wort.
Source: FDA drug label (Joyeaux), Xiromed, LLC, effective October 18, 2024 (SPL set 655b2c93-cfae-d44f-c128-c816bbd88e45), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aprepitant | Ethinyl estradiol/ferrous fumarate/levonorgestrel | |
|---|---|---|
| Labeled for | Nausea and vomiting | Birth control |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $46.42 per capsule 40 mg capsule | $3.45 per tablet 28 tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once