What the FDA labels say about taking them together
Apremilast and rifampin
Apremilast's FDA label of September 2, 2026 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name apremilast. The apremilast label: “Use with strong cytochrome P450 enzyme inducers is not recommended because loss of efficacy may occur”
Check it at the source: the apremilast FDA label on DailyMed (effective September 2, 2026, Amgen, Inc); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the apremilast label say about rifampin?
Apremilast label, drug interactionsDRUG INTERACTIONS 7.1 Strong CYP450 Inducers Co-administration with strong CYP450 inducers (such as rifampin) decreases apremilast exposure and may result in loss of efficacy of OTEZLA/OTEZLA XR [see Warnings and Precautions (5.5) and Clinical Pharmacology (12.3) ].
Apremilast label, warnings and precautionsUse with strong cytochrome P450 enzyme inducers (e.g., rifampin, phenobarbital, carbamazepine, phenytoin) is not recommended because loss of efficacy may occur
Source: FDA drug label (Otezla), Amgen, Inc, effective September 2, 2026 (SPL set f6b1f516-4972-4d82-bced-113e47b41cc5), via openFDA; the full label on DailyMed
What does the rifampin label say about apremilast?
Rifampin's label (effective February 11, 2026) does not name apremilast in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Apremilast | Rifampin | |
|---|---|---|
| Labeled for | Psoriasis | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $90.57 per tablet 30 mg tablet | $0.679 per capsule 300 mg capsule |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once