What the FDA labels say about taking them together
Apraclonidine and clonidine
Apraclonidine's FDA label of May 8, 2026 names clonidine in its contraindications section; the clonidine labels PlainMeds reads (4) do not name apraclonidine. The apraclonidine label: “Systemic clonidine may inhibit the production of catecholamines in response to insulin-induced hypoglycemia and mask the signs and symptoms of hypoglycemia.”
Check it at the source: the apraclonidine FDA label on DailyMed (effective May 8, 2026, Harrow Eye, LLC); the clonidine FDA label on DailyMed (effective March 30, 2026, Unichem Pharmaceuticals (USA), Inc.).
What does the apraclonidine label say about clonidine?
Apraclonidine label, contraindicationsCONTRAINDICATIONS IOPIDINE 1% Ophthalmic Solution is contraindicated for patients receiving monoamine oxidase inhibitor therapy and for patients with hypersensitivity to any component of this medication or to clonidine.
Apraclonidine label (Sandoz Inc, October 2, 2024), contraindicationsCONTRAINDICATIONS Apraclonidine ophthalmic solution 0.5% is contraindicated in patients with hypersensitivity to apraclonidine or any other component of this medication, as well as systemic clonidine.
Apraclonidine label (Sandoz Inc, October 2, 2024), drug interactionsSystemic clonidine may inhibit the production of catecholamines in response to insulin-induced hypoglycemia and mask the signs and symptoms of hypoglycemia.
Source: FDA drug label (Apraclonidine, NDA020258), Sandoz Inc, effective October 2, 2024 (SPL set 04ad82af-e7ba-4f40-a120-be9d33cf0c7b), via openFDA
Source: FDA drug label (IOPIDINE 1%), Harrow Eye, LLC, effective May 8, 2026 (SPL set 00f18845-ccde-8678-e063-6294a90a3374), via openFDA; the full label on DailyMed
What does the clonidine label say about apraclonidine?
Clonidine's label (effective March 30, 2026) and its 3 other brand-application labels do not name apraclonidine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (clonidine hydrochloride), Unichem Pharmaceuticals (USA), Inc., effective March 30, 2026 (SPL set 21bfa28f-20df-43fd-bb80-b720d3b40696), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Apraclonidine | Clonidine | |
|---|---|---|
| Labeled for | n/a | High blood pressure, ADHD, Pain |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $9.29 per mL 0.5% drops | $0.0241 per tablet 0.1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once