What the FDA labels say about taking them together
Apomorphine and nitroglycerin
Apomorphine's FDA label of February 24, 2022 names nitroglycerin in its drug interactions section; the nitroglycerin labels PlainMeds reads (4) do not name apomorphine. The apomorphine label: “Concomitant administration of 0.4 mg sublingual nitroglycerin with APOKYN in healthy subjects causes greater decreases in blood pressure compared to APOKYN alone.”
Check it at the source: the apomorphine FDA label on DailyMed (effective February 24, 2022, TruPharma, LLC); the nitroglycerin FDA label on DailyMed (effective February 15, 2023, Viatris Specialty LLC).
What does the apomorphine label say about nitroglycerin?
Apomorphine label, drug interactionsConcomitant administration of 0.4 mg sublingual nitroglycerin with apomorphine hydrocloride in healthy subjects causes greater decreases in blood pressure compared to apomorphine hydrocloride alone.
Apomorphine label, warnings and precautionsPatients taking apomorphine hydrochloride should lie down before and after taking sublingual nitroglycerin.
Onapgo label (MDD US Operations, LLC, a subsidiary of Supernus Pharmaceuticals, Inc, July 10, 2026), drug interactionsIn a study of healthy subjects, concomitant administration of 0.4 mg sublingual nitroglycerin with subcutaneous apomorphine caused greater decreases in blood pressure than with subcutaneous apomorphine alone [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (Onapgo, NDA214056), MDD US Operations, LLC, a subsidiary of Supernus Pharmaceuticals, Inc, effective July 10, 2026 (SPL set f3552b6e-5ae7-4993-aa1a-e399c4a7080a), via openFDA
Source: FDA drug label (apomorphine hydrocloride), ANDA212025 (Tp Anda Holdings), as published by TruPharma, LLC, effective February 24, 2022 (SPL set aedf70e4-1949-44bc-bf1b-0f282c4f0705), via openFDA; the full label on DailyMed
What does the nitroglycerin label say about apomorphine?
Nitroglycerin's label (effective February 15, 2023) and its 3 other brand-application labels do not name apomorphine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Nitrostat), Viatris Specialty LLC, effective February 15, 2023 (SPL set 9a52da75-d0af-4237-96c0-0b12adfa8636), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Apomorphine | Nitroglycerin | |
|---|---|---|
| Labeled for | Parkinson's disease | Angina, High blood pressure, Heart failure, Heart attack and coronary artery disease |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.127 per tablet 0.4 mg tablet sl |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once