What the FDA labels say about taking them together
Apomorphine and metoclopramide
Apomorphine's FDA label of February 24, 2022 names metoclopramide in its drug interactions section, and metoclopramide's label names apomorphine too. The apomorphine label: “… hypotension, falls, and injuries. Dopamine antagonists, such as neuroleptics or metoclopramide, may diminish the effectiveness of ONAPGO. …”
Check it at the source: the apomorphine FDA label on DailyMed (effective February 24, 2022, TruPharma, LLC); the metoclopramide FDA label on DailyMed (effective May 18, 2026, ANI Pharmaceuticals, Inc.).
What does the apomorphine label say about metoclopramide?
Apomorphine label, drug interactionsDRUG INTERACTIONS Concomitant use of antihypertensive medications and vasodilators: increased risk for hypotension, myocardial infarction, pneumonia, falls, and injuries ( 7.2 ) Dopamine antagonists such as neuroleptics or metoclopramide, may diminish the effectiveness of apomorphine hydrocloride ( 7.4 ) 7.1 5HT 3 Antagonists Based on reports of profound hypotension and loss of consciousness when apomorphine hydrocloride was administered with ondansetron, the concomitant use of apomorphine hydrocloride with 5HT 3 antagonists including antiemetics (for example, ondansetron, granisetron, dolasetron, palonosetron) and alosetron, is contraindicated.
Onapgo label (MDD US Operations, LLC, a subsidiary of Supernus Pharmaceuticals, Inc, July 10, 2026), warnings and precautionsAntiemetics with anti-dopaminergic actions (e.g., haloperidol, chlorpromazine, promethazine, prochlorperazine, metoclopramide) have the potential to worsen the symptoms in patients with Parkinson's disease (PD) and therefore the benefits and risks of treatment with these antiemetics should be carefully considered.
Source: FDA drug label (Onapgo, NDA214056), MDD US Operations, LLC, a subsidiary of Supernus Pharmaceuticals, Inc, effective July 10, 2026 (SPL set f3552b6e-5ae7-4993-aa1a-e399c4a7080a), via openFDA
Source: FDA drug label (Apokyn, NDA021264), MDD US Operations, LLC, effective October 10, 2024 (SPL set 3235535d-9ef9-4657-8b2a-176a807d091c), via openFDA
Source: FDA drug label (apomorphine hydrocloride), ANDA212025 (Tp Anda Holdings), as published by TruPharma, LLC, effective February 24, 2022 (SPL set aedf70e4-1949-44bc-bf1b-0f282c4f0705), via openFDA; the full label on DailyMed
What does the metoclopramide label say about apomorphine?
Metoclopramide label, drug interactionsExamples; apomorphine, bromocriptine, cabergoline, levodopa, pramipexole, ropinirole, and rotigotine
Source: FDA drug label (Metoclopramide), NDA017854 (Ani Pharms), as published by ANI Pharmaceuticals, Inc., effective May 18, 2026 (SPL set 797aad80-0597-42f8-99d5-39de180c3b5a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Apomorphine | Metoclopramide | |
|---|---|---|
| Labeled for | Parkinson's disease | Acid reflux and ulcers, Nausea and vomiting |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.0439 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once