What the FDA labels say about taking them together
Anakinra and infliximab
Infliximab's FDA label of August 28, 2026 names anakinra in its drug interactions section; the anakinra label PlainMeds reads does not name infliximab. The infliximab label: “An increased risk of serious infections was seen in clinical studies of other TNF blockers used in combination with anakinra or abatacept, with no added clinical benefit.”
Check it at the source: the anakinra FDA label on DailyMed (effective April 3, 2026, Swedish Orphan Biovitrum AB (publ)); the infliximab FDA label on DailyMed (effective August 28, 2026).
What does the anakinra label say about infliximab?
Anakinra's label (effective April 3, 2026) does not name infliximab in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Kineret), Swedish Orphan Biovitrum AB (publ), effective April 3, 2026 (SPL set d9d74915-6606-4570-9c52-c4001d3177de), via openFDA; the full label on DailyMed
What does the infliximab label say about anakinra?
Infliximab label, drug interactionsAn increased risk of serious infections was seen in clinical studies of other TNF blockers used in combination with anakinra or abatacept, with no added clinical benefit.
Infliximab label, warnings and precautionsBecause of the nature of the adverse reactions seen with the concurrent use of etanercept and anakinra therapy, similar toxicities may also result from the concurrent use of anakinra and other TNF blockers.
Source: FDA drug label (Renflexis), Organon LLC, effective August 28, 2026 (SPL set dbf738c4-3fac-4422-a9d8-51d9c83a8789), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Anakinra | Infliximab | |
|---|---|---|
| Labeled for | n/a | Rheumatoid arthritis, Crohn's disease and ulcerative colitis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once