What the FDA labels say about taking them together
Anakinra and etanercept
Anakinra's FDA label of April 3, 2026 names etanercept in its drug interactions section, and etanercept's label names anakinra too. The etanercept label: “Recommended for Use with Anakinra or Abatacept Use of Enbrel with anakinra or abatacept is not recommended.”
Check it at the source: the anakinra FDA label on DailyMed (effective April 3, 2026, Swedish Orphan Biovitrum AB (publ)); the etanercept FDA label on DailyMed (effective May 11, 2026, Immunex Corporation).
What does the anakinra label say about etanercept?
Anakinra label, drug interactionsA higher rate of serious infections has been observed in RA patients treated with concurrent KINERET and etanercept therapy than in patients treated with etanercept alone.
Anakinra label, warnings and precautionsIn a 24-week study of concurrent KINERET and etanercept therapy in RA patients, the rate of serious infections in the combination arm (7%) was higher than with etanercept alone (0%).
Source: FDA drug label (Kineret), Swedish Orphan Biovitrum AB (publ), effective April 3, 2026 (SPL set d9d74915-6606-4570-9c52-c4001d3177de), via openFDA; the full label on DailyMed
What does the etanercept label say about anakinra?
Etanercept label, drug interactionsLive vaccines – Avoid concurrent administration with Enbrel ( 5.8 , 7.1 ) Anakinra – Increased risk of serious infection ( 5.12 , 7.2 ) Abatacept – Increased risk of serious adverse events, including infections ( 5.12 , 7.2 ) Cyclophosphamide – Not recommended for use with Enbrel.
Etanercept label, warnings and precautionsRecommended for Use with Anakinra or Abatacept Use of Enbrel with anakinra or abatacept is not recommended [see Drug Interactions (7.2) ].
Source: FDA drug label (ENBREL), Immunex Corporation, effective May 11, 2026 (SPL set a002b40c-097d-47a5-957f-7a7b1807af7f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Anakinra | Etanercept | |
|---|---|---|
| Labeled for | n/a | Rheumatoid arthritis, Psoriasis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $2,084.14 per mL 25 mg/0.5 mL syringe |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once