What the FDA labels say about taking them together
Anagrelide and methadone
Anagrelide's FDA label of April 8, 2026 names methadone in its drug interactions section; the methadone labels PlainMeds reads (4) do not name anagrelide. The anagrelide label: “Drugs that Prolong QT Avoid use of AGRYLIN in patients taking medications that may prolong QT interval.”
Check it at the source: the anagrelide FDA label on DailyMed (effective April 8, 2026, Takeda Pharmaceuticals America, Inc.); the methadone FDA label on DailyMed (effective December 8, 2025, Epic Pharma, LLC).
What does the anagrelide label say about methadone?
Anagrelide label, drug interactionsDrugs that Prolong QT Avoid use of AGRYLIN in patients taking medications that may prolong QT interval (including, but not limited to, chloroquine, clarithromycin, haloperidol, methadone, moxifloxacin, amiodarone, disopyramide, procainamide, and pimozide) [see Warnings and Precautions (5.1) and Clinical Pharmacology (12.2) ].
Source: FDA drug label (Agrylin), Takeda Pharmaceuticals America, Inc., effective April 8, 2026 (SPL set cb960074-99c1-4a73-941f-f0644a7ec219), via openFDA; the full label on DailyMed
What does the methadone label say about anagrelide?
Methadone's label (effective December 8, 2025) and its 3 other brand-application labels do not name anagrelide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methadone Hydrochloride), Epic Pharma, LLC, effective December 8, 2025 (SPL set 6da7501b-b881-4bc7-891a-74214a00a3ac), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Anagrelide | Methadone | |
|---|---|---|
| Labeled for | n/a | Pain, Opioid use disorder |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.729 per capsule 0.5 mg capsule | $0.177 per tablet 10 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once