What the FDA labels say about taking them together
Ampicillin and hydroxychloroquine
Hydroxychloroquine's FDA label of October 8, 2024 names ampicillin in its drug interactions section; the ampicillin label PlainMeds reads does not name hydroxychloroquine. The hydroxychloroquine label: “In a study of healthy volunteers, chloroquine significantly reduced the bioavailability of ampicillin.”
Check it at the source: the ampicillin FDA label on DailyMed (effective February 21, 2025, Sandoz Inc); the hydroxychloroquine FDA label on DailyMed (effective October 8, 2024, ANI Pharmaceuticals, Inc.).
What does the ampicillin label say about hydroxychloroquine?
Ampicillin's label (effective February 21, 2025) does not name hydroxychloroquine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ampicillin), Sandoz Inc, effective February 21, 2025 (SPL set 64a04e8c-8f78-46b3-8f45-56ef225a4f74), via openFDA; the full label on DailyMed
What does the hydroxychloroquine label say about ampicillin?
Hydroxychloroquine label, drug interactionsIn a study of healthy volunteers, chloroquine significantly reduced the bioavailability of ampicillin.
Source: FDA drug label (SOVUNA), ANI Pharmaceuticals, Inc., effective October 8, 2024 (SPL set dd441154-b196-4d4c-bc56-2e37f345ef8d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ampicillin | Hydroxychloroquine | |
|---|---|---|
| Labeled for | Bacterial infections, Urinary tract infections | Rheumatoid arthritis |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.441 per capsule 500 mg capsule | $0.149 per tablet 200 mg tablet |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once