What the FDA labels say about taking them together
Amphetamine and sodium bicarbonate
Amphetamine's FDA label of August 20, 2026 names sodium bicarbonate in its drug interactions section; the sodium bicarbonate labels PlainMeds reads (3) do not name amphetamine. The amphetamine label: “Alkalinizing agents Gastrointestinal alkalinizing agents (sodium bicarbonate, etc.) increase absorption of amphetamines.”
Check it at the source: the amphetamine FDA label on DailyMed (effective August 20, 2026, Aurolife Pharma, LLC); the sodium bicarbonate FDA label on DailyMed (effective August 4, 2026).
What does the amphetamine label say about sodium bicarbonate?
Amphetamine label, drug interactionsAlkalinizing agents Gastrointestinal alkalinizing agents (sodium bicarbonate, etc.) increase absorption of amphetamines.
Source: FDA drug label (Amphetamine Sulfate), Aurolife Pharma, LLC, effective August 20, 2026 (SPL set 20735c2e-6304-425f-a4e4-584f6f90d6a0), via openFDA; the full label on DailyMed
What does the sodium bicarbonate label say about amphetamine?
Sodium bicarbonate's label (effective August 4, 2026) and its 2 other brand-application labels do not name amphetamine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Sodium Bicarbonate 5 gr), TWIN MED LLC, effective August 4, 2026 (SPL set e325d899-d9a6-5adb-e053-2995a90ac861), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amphetamine | Sodium bicarbonate | |
|---|---|---|
| Labeled for | ADHD | Acid reflux and ulcers, Diarrhea |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.449 per tablet 10 mg tablet | $0.154 per mL 8.4% vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once