What the FDA labels say about taking them together
Amphetamine and lisdexamfetamine
Lisdexamfetamine's FDA label of April 30, 2026 names amphetamine in its contraindications section; amphetamine's label does not name lisdexamfetamine itself but warns about its class (Stimulants). The lisdexamfetamine label: “DRUG INTERACTIONS Acidifying and Alkalinizing Agents: Agents that alter urinary pH can alter blood levels of amphetamine.”
Check it at the source: the amphetamine FDA label on DailyMed (effective August 20, 2026, Aurolife Pharma, LLC); the lisdexamfetamine FDA label on DailyMed (effective April 30, 2026, Takeda Pharmaceuticals America, Inc.).
What does the amphetamine label say about lisdexamfetamine?
Amphetamine's label does not name lisdexamfetamine itself; it warns about its class (Stimulants):
Amphetamine label, boxed warningMISUSE AND ABUSE OF CNS STIMULANTS, INCLUDING AMPHETAMINE SULFATE, CAN RESULT IN OVERDOSE AND DEATH (SEE OVERDOSAGE)], AND THIS RISK IS INCREASED WITH HIGHER DOSES OR UNAPPROVED METHODS OF ADMINISTRATION, SUCH AS SNORTING OR INJECTION.
Amphetamine label, warningsIf concomitant use of Amphetamine Sulfate Tablets with other serotonergic drugs or CYP2D6 inhibitors is clinically warranted, initiate Amphetamine Sulfate Tablets with lower doses, monitor patients for the emergence of serotonin syndrome during drug initiation or titration, and inform patients of the increased risk for serotonin syndrome. …
Source: FDA drug label (Amphetamine Sulfate), Aurolife Pharma, LLC, effective August 20, 2026 (SPL set 20735c2e-6304-425f-a4e4-584f6f90d6a0), via openFDA; the full label on DailyMed
What does the lisdexamfetamine label say about amphetamine?
Lisdexamfetamine label, contraindicationsCONTRAINDICATIONS VYVANSE is contraindicated in patients with: Known hypersensitivity to amphetamine products or other ingredients of VYVANSE.
Lisdexamfetamine label, drug interactionsDRUG INTERACTIONS Acidifying and Alkalinizing Agents: Agents that alter urinary pH can alter blood levels of amphetamine.
Lisdexamfetamine label, warnings and precautionsWorsening of Tourette's Syndrome CNS stimulants, including amphetamine, have been associated with the onset or exacerbation of motor and verbal tics.
Source: FDA drug label (Arynta, NDA219847), Azurity Pharmaceuticals, Inc., effective July 30, 2025 (SPL set 71cdfc97-96af-4378-a44a-6d5d77e7d6b7), via openFDA
Source: FDA drug label (Vyvanse), Takeda Pharmaceuticals America, Inc., effective April 30, 2026 (SPL set 704e4378-ca83-445c-8b45-3cfa51c1ecad), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amphetamine | Lisdexamfetamine | |
|---|---|---|
| Labeled for | ADHD | ADHD, Binge eating disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.449 per tablet 10 mg tablet | $2.44 per capsule 20 mg capsule |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once