What the FDA labels say about taking them together
Amphetamine and desipramine
Amphetamine's FDA label of August 20, 2026 names desipramine in its drug interactions section; the desipramine labels PlainMeds reads (2) do not name amphetamine. The amphetamine label: “Antidepressants tricyclic Amphetamines may enhance the activity of tricyclic or sympathomimetic agents; d-amphetamine with desipramine or protriptyline and possibly other tricyclics cause striking and sustained …”
Check it at the source: the amphetamine FDA label on DailyMed (effective August 20, 2026, Aurolife Pharma, LLC); the desipramine FDA label on DailyMed (effective July 9, 2025, Alembic Pharmaceuticals Inc.).
What does the amphetamine label say about desipramine?
Amphetamine label, drug interactionsAntidepressants tricyclic Amphetamines may enhance the activity of tricyclic or sympathomimetic agents; d-amphetamine with desipramine or protriptyline and possibly other tricyclics cause striking and sustained increases in the concentration of d- amphetamine in the brain; cardiovascular effects can be potentiated.
Source: FDA drug label (Amphetamine Sulfate), Aurolife Pharma, LLC, effective August 20, 2026 (SPL set 20735c2e-6304-425f-a4e4-584f6f90d6a0), via openFDA; the full label on DailyMed
What does the desipramine label say about amphetamine?
Desipramine's label (effective July 9, 2025) and its 1 other brand-application label do not name amphetamine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (DESIPRAMINE HYDROCHLORIDE), Alembic Pharmaceuticals Inc., effective July 9, 2025 (SPL set cad14805-64d8-4257-b5f1-d56e0063f0e2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amphetamine | Desipramine | |
|---|---|---|
| Labeled for | ADHD | Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.449 per tablet 10 mg tablet | $0.276 per tablet 75 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once