What the FDA labels say about taking them together
Amphetamine and codeine/phenylephrine/promethazine
Codeine/phenylephrine/promethazine's FDA label of January 8, 2026 names amphetamine in its drug interactions section; the amphetamine labels PlainMeds reads (3) do not name codeine/phenylephrine/promethazine.
Check it at the source: the amphetamine FDA label on DailyMed (effective August 20, 2026, Aurolife Pharma, LLC); the codeine/phenylephrine/promethazine FDA label on DailyMed (effective January 8, 2026, Amneal Pharmaceuticals LLC).
What does the amphetamine label say about codeine/phenylephrine/promethazine?
Amphetamine's label (effective August 20, 2026) and its 2 other brand-application labels do not name codeine/phenylephrine/promethazine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amphetamine Sulfate), Aurolife Pharma, LLC, effective August 20, 2026 (SPL set 20735c2e-6304-425f-a4e4-584f6f90d6a0), via openFDA; the full label on DailyMed
What does the codeine/phenylephrine/promethazine label say about amphetamine?
Codeine/phenylephrine/promethazine label, drug interactionsDue to synergistic adrenergic effects of phenylephrine, one of the active ingredients in Promethazine and Phenylephrine HCl and Codeine Phosphate Oral Solution, the concomitant use of Promethazine and Phenylephrine HCl and Codeine Phosphate Oral Solution with sympathomimetic amines such as epinephrine, amphetamine, phenylpropanolamine, and bronchodilator beta 2 -adrenoreceptor agonists may result in tachycardia, arrhythmias, serious hypertensive response and possible stroke.
Source: FDA drug label (Promethazine and Phenylephrine HCl, and Codeine Phosphate), Amneal Pharmaceuticals LLC, effective January 8, 2026 (SPL set 5f23b254-872b-4e88-91be-710c3ea7687b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amphetamine | Codeine/phenylephrine/promethazine | |
|---|---|---|
| Labeled for | ADHD | Cough and cold |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.449 per tablet 10 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once