What the FDA labels say about taking them together
Amphetamine and buspirone
Amphetamine's FDA label of August 20, 2026 names buspirone in its warnings section; the buspirone label PlainMeds reads does not name amphetamine. The amphetamine label: “… triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. John’s Wort [ see Drug Interactions ].”
Check it at the source: the amphetamine FDA label on DailyMed (effective August 20, 2026, Aurolife Pharma, LLC); the buspirone FDA label on DailyMed (effective December 22, 2023, Unichem Pharmaceuticals (USA), Inc.).
What does the amphetamine label say about buspirone?
Amphetamine label, warningsSerotonin Syndrome Serotonin syndrome, a potentially life-threatening reaction, may occur when amphetamines are used in combination with other drugs that affect the serotonergic neurotransmitter systems such as monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. John's Wort (see DRUG INTERACTIONS).
Source: FDA drug label (Dyanavel Xr, NDA208147), NextWave Pharmaceuticals, Inc, effective February 24, 2026 (SPL set ae304b29-0b40-40ec-ad0d-76b742d4a9b9), via openFDA
Source: FDA drug label (Amphetamine Sulfate), Aurolife Pharma, LLC, effective August 20, 2026 (SPL set 20735c2e-6304-425f-a4e4-584f6f90d6a0), via openFDA; the full label on DailyMed
What does the buspirone label say about amphetamine?
Buspirone's label (effective December 22, 2023) does not name amphetamine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Buspirone Hydrochloride), Unichem Pharmaceuticals (USA), Inc., effective December 22, 2023 (SPL set a6bdf140-075e-445e-a62d-633a4b97f3a8), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amphetamine | Buspirone | |
|---|---|---|
| Labeled for | ADHD | Anxiety |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.449 per tablet 10 mg tablet | $0.043 per tablet 15 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once