What the FDA labels say about taking them together
Amoxicillin/omeprazole/rifabutin and ampicillin
Amoxicillin/omeprazole/rifabutin's FDA label of December 23, 2025 names ampicillin in its drug interactions section; the ampicillin label PlainMeds reads does not name amoxicillin/omeprazole/rifabutin. The amoxicillin/omeprazole/rifabutin label: “Clinical Impact; High urine concentrations of ampicillin or amoxicillin may result in false-positive reactions when using glucose tests based on the Benedict’s copper reduction reaction that determines the amount of …”
Check it at the source: the amoxicillin/omeprazole/rifabutin FDA label on DailyMed (effective December 23, 2025, RedHill Biopharma Ltd); the ampicillin FDA label on DailyMed (effective February 21, 2025, Sandoz Inc).
What does the amoxicillin/omeprazole/rifabutin label say about ampicillin?
Amoxicillin/omeprazole/rifabutin label, drug interactionsClinical Impact; High urine concentrations of ampicillin or amoxicillin may result in false-positive reactions when using glucose tests based on the Benedict’s copper reduction reaction that determines the amount of reducing substances like glucose in the urine.
Source: FDA drug label (Talicia), NDA213004 (Talicia Holdings), as published by RedHill Biopharma Ltd, effective December 23, 2025 (SPL set 68c4e9dc-dbcf-4151-b6f7-5e4b9922b76f), via openFDA; the full label on DailyMed
What does the ampicillin label say about amoxicillin/omeprazole/rifabutin?
Ampicillin's label (effective February 21, 2025) does not name amoxicillin/omeprazole/rifabutin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ampicillin), Sandoz Inc, effective February 21, 2025 (SPL set 64a04e8c-8f78-46b3-8f45-56ef225a4f74), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amoxicillin/omeprazole/rifabutin | Ampicillin | |
|---|---|---|
| Labeled for | n/a | Bacterial infections, Urinary tract infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $4.88 per capsule 10-250-12.5 mg capsule | $0.441 per capsule 500 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once