What the FDA labels say about taking them together
Amoxicillin/clarithromycin/lansoprazole and chloramphenicol
Amoxicillin/clarithromycin/lansoprazole's FDA label of February 19, 2025 names chloramphenicol in its drug interactions section; the chloramphenicol label PlainMeds reads does not name amoxicillin/clarithromycin/lansoprazole. The amoxicillin/clarithromycin/lansoprazole label: “Decreased and delayed absorption of lansoprazole.”
Check it at the source: the amoxicillin/clarithromycin/lansoprazole FDA label on DailyMed (effective February 19, 2025, Rising Pharma Holdings, Inc.); the chloramphenicol FDA label on DailyMed (effective October 10, 2024, Fresenius Kabi USA, LLC).
What does the amoxicillin/clarithromycin/lansoprazole label say about chloramphenicol?
Amoxicillin/clarithromycin/lansoprazole label, drug interactionsClinical Impact: Decreased and delayed absorption of lansoprazole (…). … amoxicillin and probenecid may result in increased and prolonged blood levels of amoxicillin. Antibiotics Chloramphenicol, macrolides, sulfonamides, and tetracyclines may interfere with bactericidal effects of penicillin. This has been demonstrated in vitro; …
Source: FDA drug label (Lansoprazole, Amoxicillin, Clarithromycin), Rising Pharma Holdings, Inc., effective February 19, 2025 (SPL set 40adc1d3-7ce7-4698-aa7f-b5dbaaecec00), via openFDA; the full label on DailyMed
What does the chloramphenicol label say about amoxicillin/clarithromycin/lansoprazole?
Chloramphenicol's label (effective October 10, 2024) does not name amoxicillin/clarithromycin/lansoprazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Chloramphenicol Sodium Succinate), Fresenius Kabi USA, LLC, effective October 10, 2024 (SPL set aed29594-211d-49ef-813f-131975a8d0e3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amoxicillin/clarithromycin/lansoprazole | Chloramphenicol | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $6.04 per unit Lansoprazol-amoxicil-clarithro | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once