What the FDA labels say about taking them together
Amoxicillin and vonoprazan
Vonoprazan's FDA label of July 16, 2026 names amoxicillin in its contraindications section; the amoxicillin labels PlainMeds reads (2) do not name vonoprazan. The vonoprazan label: “… reactions, including potentially fatal arrhythmias, and is contraindicated. Amoxicillin also has drug interactions.”
Check it at the source: the amoxicillin FDA label on DailyMed (effective February 22, 2024, Sandoz Inc); the vonoprazan FDA label on DailyMed (effective July 16, 2026, Phathom Pharmaceuticals Inc.).
What does the amoxicillin label say about vonoprazan?
Amoxicillin's label (effective February 22, 2024) and its 1 other brand-application label do not name vonoprazan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amoxicillin), Sandoz Inc, effective February 22, 2024 (SPL set 13bd4214-9b7f-425b-af5f-fc1ddc678230), via openFDA; the full label on DailyMed
What does the vonoprazan label say about amoxicillin?
Vonoprazan label, contraindicationsFor information about contraindications of antibacterial agents (clarithromycin and amoxicillin) indicated in combination with VOQUEZNA, refer to the Contraindications section of the corresponding prescribing information.
Vonoprazan label, drug interactionsClinical Effect; Concomitant administration of clarithromycin with other drugs can lead to serious adverse reactions, including potentially fatal arrhythmias, and is contraindicated. Amoxicillin also has drug interactions.
Vonoprazan label, warnings and precautionsFor more information specific to antibacterial agents (clarithromycin and amoxicillin) indicated for use in combination with VOQUEZNA, refer to the Warnings and Precautions section of the corresponding prescribing information.
Source: FDA drug label (VOQUEZNA), Phathom Pharmaceuticals Inc., effective July 16, 2026 (SPL set 0cc52ac5-77ec-4d66-a770-762a1a960914), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amoxicillin | Vonoprazan | |
|---|---|---|
| Labeled for | Bacterial infections, Acid reflux and ulcers | Acid reflux and ulcers |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0788 per capsule 500 mg capsule | $22.41 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once