What the FDA labels say about taking them together
Amoxicillin and omeprazole
Omeprazole's FDA label of April 22, 2024 names amoxicillin in its contraindications section; the amoxicillin labels PlainMeds reads (2) do not name omeprazole. The omeprazole label: “Concomitant administration of clarithromycin with other drugs can lead to serious adverse reactions, including potentially fatal arrhythmias, and are contraindicated.”
Check it at the source: the amoxicillin FDA label on DailyMed (effective February 22, 2024, Sandoz Inc); the omeprazole FDA label on DailyMed (effective April 22, 2024, Apotex Corp).
What does the amoxicillin label say about omeprazole?
Amoxicillin's label (effective February 22, 2024) and its 1 other brand-application label do not name omeprazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amoxicillin), Sandoz Inc, effective February 22, 2024 (SPL set 13bd4214-9b7f-425b-af5f-fc1ddc678230), via openFDA; the full label on DailyMed
What does the omeprazole label say about amoxicillin?
Omeprazole label, contraindicationsFor information about contraindications of antibacterial agents (clarithromycin and amoxicillin) indicated in combination with omeprazole, refer to the CONTRAINDICATIONS section of their package inserts.
Omeprazole label, drug interactionsCombination Therapy with Clarithromycin and Amoxicillin Clinical Impact: Concomitant administration of clarithromycin with other drugs can lead to serious adverse reactions, including potentially fatal arrhythmias, and are contraindicated.
Omeprazole label, warnings and precautionsFor more information specific to antibacterial agents (clarithromycin and amoxicillin) indicated for use in combination with omeprazole, refer to Warnings and Precautions sections of the corresponding prescribing information.
Prilosec label (Covis Pharma US, Inc, March 19, 2024), drug interactionsCombination Therapy with Clarithromycin and Amoxicillin Clinical Impact: Concomitant administration of clarithromycin with other drugs can lead to serious adverse reactions, including potentially fatal arrhythmias, and are contraindicated. Amoxicillin also has drug interactions. Intervention: See Contraindications, Warnings and Precautions in prescribing information for clarithromycin. See Drug Interactions in prescribing information for amoxicillin.
Source: FDA drug label (Prilosec, NDA022056), Covis Pharma US, Inc, effective March 19, 2024 (SPL set b6761f84-53ac-4745-a8c8-1e5427d7e179), via openFDA
Source: FDA drug label (Omeprazole), Apotex Corp, effective April 22, 2024 (SPL set b83329ac-a65e-b3af-a3fb-c5a6c740e5e7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amoxicillin | Omeprazole | |
|---|---|---|
| Labeled for | Bacterial infections, Acid reflux and ulcers | Acid reflux and ulcers |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0788 per capsule 500 mg capsule | $0.0295 per capsule 20 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once