What the FDA labels say about taking them together
Amoxicillin and estriol
Amoxicillin's FDA label of February 22, 2024 names estriol in its drug interactions section; the estriol label PlainMeds reads does not name amoxicillin. The amoxicillin label: “Following administration of ampicillin or amoxicillin to pregnant women, a transient decrease in plasma concentration of total conjugated estriol, estriol-glucuronide, conjugated estrone, and estradiol has been noted.”
Check it at the source: the amoxicillin FDA label on DailyMed (effective February 22, 2024, Sandoz Inc); the estriol FDA label on DailyMed (effective August 27, 2026).
What does the amoxicillin label say about estriol?
Amoxicillin label, drug interactionsFollowing administration of ampicillin or amoxicillin to pregnant women, a transient decrease in plasma concentration of total conjugated estriol, estriol-glucuronide, conjugated estrone, and estradiol has been noted.
Source: FDA drug label (Amoxicillin), Sandoz Inc, effective February 22, 2024 (SPL set 13bd4214-9b7f-425b-af5f-fc1ddc678230), via openFDA; the full label on DailyMed
What does the estriol label say about amoxicillin?
Estriol's label (effective August 27, 2026) does not name amoxicillin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Estriol Cream), Guangxi Keyun E-commerce Co., Ltd., effective August 27, 2026 (SPL set 4deadcb6-0d46-bdd7-e063-6294a90a26d7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amoxicillin | Estriol | |
|---|---|---|
| Labeled for | Bacterial infections, Acid reflux and ulcers | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0788 per capsule 500 mg capsule | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once