What the FDA labels say about taking them together
Amoxicillin and azithromycin
Azithromycin's FDA label of December 4, 2025 names amoxicillin in its warnings and precautions section; the amoxicillin labels PlainMeds reads (2) do not name azithromycin. The azithromycin label: “… exposed to azithromycin relative to other antibacterial drugs, including amoxicillin.”
Check it at the source: the amoxicillin FDA label on DailyMed (effective February 22, 2024, Sandoz Inc); the azithromycin FDA label on DailyMed (effective December 4, 2025, Bionpharma Inc.).
What does the amoxicillin label say about azithromycin?
Amoxicillin's label (effective February 22, 2024) and its 1 other brand-application label do not name azithromycin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amoxicillin), Sandoz Inc, effective February 22, 2024 (SPL set 13bd4214-9b7f-425b-af5f-fc1ddc678230), via openFDA; the full label on DailyMed
What does the azithromycin label say about amoxicillin?
Azithromycin label, warnings and precautionsSome observational studies have shown an approximately two-fold increased short-term potential risk of acute cardiovascular death in adults exposed to azithromycin relative to other antibacterial drugs, including amoxicillin.
Source: FDA drug label (Zithromax, NDA050711), Pfizer Laboratories Div Pfizer Inc, effective July 24, 2026 (SPL set db52b91e-79f7-4cc1-9564-f2eee8e31c45), via openFDA
Source: FDA drug label (Azithromycin), Bionpharma Inc., effective December 4, 2025 (SPL set 859bb02c-a4bc-46fa-9fc9-def1219b5dfb), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amoxicillin | Azithromycin | |
|---|---|---|
| Labeled for | Bacterial infections, Acid reflux and ulcers | Bacterial infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0788 per capsule 500 mg capsule | $0.266 per tablet 250 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once