What the FDA labels say about taking them together
Amoxapine and loxapine
Loxapine's FDA label (Adasuve) of July 6, 2026 names amoxapine in its contraindications section; the amoxapine label PlainMeds reads does not name loxapine. The loxapine label: “… bronchospasm following ADASUVE treatment Known hypersensitivity to loxapine or amoxapine.”
Check it at the source: the amoxapine FDA label on DailyMed (effective December 18, 2024, Chartwell RX, LLC); the loxapine FDA label on DailyMed (effective February 26, 2025, Elite Laboratories, Inc.).
What does the amoxapine label say about loxapine?
Amoxapine's label (effective December 18, 2024) does not name loxapine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amoxapine), Chartwell RX, LLC, effective December 18, 2024 (SPL set eed5e856-dd7b-4eaa-9dad-508f2bef9328), via openFDA; the full label on DailyMed
What does the loxapine label say about amoxapine?
Adasuve label (Alexza Pharmaceuticals, Inc., July 6, 2026), contraindicationsCONTRAINDICATIONS ADASUVE is contraindicated in patients with the following: Current diagnosis or history of asthma, COPD, or other lung disease associated with bronchospasm [see Warnings and Precautions (5.1) ] Acute respiratory symptoms or signs (e.g., wheezing) [see Warnings and Precautions (5.1) ] Current use of medications to treat airways disease, such as asthma or COPD [see Warnings and Precautions (5.1) ] History of bronchospasm following ADASUVE treatment [see Warnings and Precautions (5.1) ] Known hypersensitivity to loxapine or amoxapine.
Source: FDA drug label (Adasuve, NDA022549), Alexza Pharmaceuticals, Inc., effective July 6, 2026 (SPL set 50e11732-7387-452d-b3e6-db3a431d5c4a), via openFDA
Source: FDA drug label (Loxapine), Elite Laboratories, Inc., effective February 26, 2025 (SPL set a0cc7bb6-075f-47d1-8935-eb77a29d8c45), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amoxapine | Loxapine | |
|---|---|---|
| Labeled for | Depression, Anxiety | Schizophrenia |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $0.468 per capsule 10 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once