What the FDA labels say about taking them together
Amlodipine and itraconazole
Amlodipine's FDA label of February 15, 2023 names itraconazole in its drug interactions section; itraconazole's label does not name amlodipine itself but warns about its class (Calcium channel blockers, Calcium channel blockers (dihydropyridines)). The amlodipine label: “However, strong inhibitors of CYP3A may increase the plasma concentrations of amlodipine to a greater extent.”
Check it at the source: the amlodipine FDA label on DailyMed (effective February 15, 2023, Viatris Specialty LLC); the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.).
What does the amlodipine label say about itraconazole?
Amlodipine label, drug interactionsHowever, strong inhibitors of CYP3A (e.g., itraconazole, clarithromycin) may increase the plasma concentrations of amlodipine to a greater extent [see Drug Interactions (7.1) ].
Source: FDA drug label (Norvasc), Viatris Specialty LLC, effective February 15, 2023 (SPL set 7367289c-b0b0-466a-83e2-558e2985c29f), via openFDA; the full label on DailyMed
What does the itraconazole label say about amlodipine?
Itraconazole's label does not name amlodipine itself; it warns about its class (Calcium channel blockers, Calcium channel blockers (dihydropyridines)):
Itraconazole label, drug interactionsCalcium Channel Blockers Felodipine Nisoldipine Contraindicated during and 2 weeks after SPORANOX ® treatment.
Itraconazole label, drug interactionsCalcium Channel Blockers Diltiazem Monitor for adverse reactions.
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amlodipine | Itraconazole | |
|---|---|---|
| Labeled for | High blood pressure, Angina, Heart attack and coronary artery disease | Fungal infections |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0102 per tablet 5 mg tablet | $0.910 per capsule 100 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once