What the FDA labels say about taking them together
Amlodipine and avanafil
Avanafil's FDA label of December 17, 2025 names amlodipine in its drug interactions section; the amlodipine labels PlainMeds reads (4) do not name avanafil.
Check it at the source: the amlodipine FDA label on DailyMed (effective February 15, 2023, Viatris Specialty LLC); the avanafil FDA label on DailyMed (effective December 17, 2025, Camber Pharmaceuticals, Inc.).
What does the amlodipine label say about avanafil?
Amlodipine's label (effective February 15, 2023) and its 3 other brand-application labels do not name avanafil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Norvasc), Viatris Specialty LLC, effective February 15, 2023 (SPL set 7367289c-b0b0-466a-83e2-558e2985c29f), via openFDA; the full label on DailyMed
What does the avanafil label say about amlodipine?
Avanafil label, drug interactionsA clinical pharmacology trial was conducted to assess the effect of avanafil on the potentiation of the blood pressure-lowering effects of selected antihypertensive medications (amlodipine and enalapril).
Source: FDA drug label (Avanafil), ANDA209266 (Hetero Labs Ltd V), as published by Camber Pharmaceuticals, Inc., effective December 17, 2025 (SPL set 1d04e17d-7399-430a-a8bb-fa1912b155e9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amlodipine | Avanafil | |
|---|---|---|
| Labeled for | High blood pressure, Angina, Heart attack and coronary artery disease | Erectile dysfunction |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0102 per tablet 5 mg tablet | $50.00 per tablet 200 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once