What the FDA labels say about taking them together
Amitriptyline/perphenazine and atropine
Amitriptyline/perphenazine's FDA label of August 30, 2025 names atropine in its drug interactions section; the atropine labels PlainMeds reads (4) do not name amitriptyline/perphenazine.
Check it at the source: the amitriptyline/perphenazine FDA label on DailyMed (effective August 30, 2025, Mylan Pharmaceuticals Inc.); the atropine FDA label on DailyMed (effective May 18, 2026, Hospira, Inc.).
What does the amitriptyline/perphenazine label say about atropine?
Amitriptyline/perphenazine label, drug interactionsUse with caution in patients who are receiving atropine or related drugs because of the additive anticholinergic effects and also in patients who will be exposed to extreme heat or organic phosphate insecticides.
Source: FDA drug label (Perphenazine and Amitriptyline Hydrochloride), Mylan Pharmaceuticals Inc., effective August 30, 2025 (SPL set e2937445-c015-c9a5-52f8-a2959da97290), via openFDA; the full label on DailyMed
What does the atropine label say about amitriptyline/perphenazine?
Atropine's label (effective May 18, 2026) and its 3 other brand-application labels do not name amitriptyline/perphenazine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Atropine Sulfate), Hospira, Inc., effective May 18, 2026 (SPL set ad8916e7-206e-409e-2582-30d072845dd4), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amitriptyline/perphenazine | Atropine | |
|---|---|---|
| Labeled for | Anxiety | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $7.74 per mL 1% eye drops |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once