What the FDA labels say about taking them together
Amitriptyline and propafenone
Amitriptyline's FDA label of September 8, 2026 names propafenone in its drug interactions section; propafenone's label does not name amitriptyline itself but warns about its class (Tricyclic antidepressants).
Check it at the source: the amitriptyline FDA label on DailyMed (effective September 8, 2026, Sun Pharmaceutical Industries, Inc.); the propafenone FDA label on DailyMed (effective September 1, 2025, Strides Pharma Science Limited).
What does the amitriptyline label say about propafenone?
Amitriptyline label, drug interactionsThe drugs that inhibit cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and many that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type 1C antiarrhythmics propafenone and flecainide).
Source: FDA drug label (Amitriptyline Hydrochloride), Sun Pharmaceutical Industries, Inc., effective September 8, 2026 (SPL set 4e520c63-1cf6-40f6-a51c-3f9b0e181342), via openFDA; the full label on DailyMed
What does the propafenone label say about amitriptyline?
Propafenone's label does not name amitriptyline itself; it warns about its class (Tricyclic antidepressants):
Propafenone label, warnings and precautionsSuch drugs may include many antiarrhythmics, some phenothiazines, tricyclic antidepressants, and oral macrolides.
Source: FDA drug label (PROPAFENONE HYDROCHLORIDE), Strides Pharma Science Limited, effective September 1, 2025 (SPL set c65253ab-937f-4982-b841-69c2b9f9ccdb), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amitriptyline | Propafenone | |
|---|---|---|
| Labeled for | Depression | Atrial fibrillation |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.03 per tablet 10 mg tablet | $0.115 per tablet 150 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once