What the FDA labels say about taking them together
Amitriptyline and procarbazine
Procarbazine's FDA label of September 16, 2024 names amitriptyline in its warnings section; the amitriptyline label PlainMeds reads does not name procarbazine.
Check it at the source: the amitriptyline FDA label on DailyMed (effective September 8, 2026, Sun Pharmaceutical Industries, Inc.); the procarbazine FDA label on DailyMed (effective September 16, 2024, Leadiant Biosciences, Inc.).
What does the amitriptyline label say about procarbazine?
Amitriptyline's label (effective September 8, 2026) does not name procarbazine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amitriptyline Hydrochloride), Sun Pharmaceutical Industries, Inc., effective September 8, 2026 (SPL set 4e520c63-1cf6-40f6-a51c-3f9b0e181342), via openFDA; the full label on DailyMed
What does the procarbazine label say about amitriptyline?
Procarbazine label, warningsBecause Matulane exhibits some monoamine oxidase inhibitory activity, sympathomimetic drugs, tricyclic antidepressant drugs (eg, amitriptyline HCI, imipramine HCI) and other drugs and foods with known high tyramine content, such as wine, yogurt, ripe cheese and bananas, should be avoided.
Source: FDA drug label (Matulane), Leadiant Biosciences, Inc., effective September 16, 2024 (SPL set 1aa75a3a-18c9-49e1-91a6-293d0b7da756), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amitriptyline | Procarbazine | |
|---|---|---|
| Labeled for | Depression | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.03 per tablet 10 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once