What the FDA labels say about taking them together

Amitriptyline and iobenguane i 123

Iobenguane i 123's FDA label of January 10, 2024 names amitriptyline in its drug interactions section; the amitriptyline label PlainMeds reads does not name iobenguane i 123. The iobenguane i 123 label: “If the AdreView imaging information is essential for clinical care, consider the withdrawal of the following categories of medications if the withdrawal can be accomplished safely: antihypertensives that deplete …”

Check it at the source: the amitriptyline FDA label on DailyMed (effective September 8, 2026, Sun Pharmaceutical Industries, Inc.); the iobenguane i 123 FDA label on DailyMed (effective January 10, 2024).

What does the amitriptyline label say about iobenguane i 123?

Amitriptyline's label (effective September 8, 2026) does not name iobenguane i 123 in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Amitriptyline Hydrochloride), Sun Pharmaceutical Industries, Inc., effective September 8, 2026 (SPL set 4e520c63-1cf6-40f6-a51c-3f9b0e181342), via openFDA; the full label on DailyMed

What does the iobenguane i 123 label say about amitriptyline?

Iobenguane i 123 label, drug interactions
DRUG INTERACTIONS The following drugs have the potential to decrease the uptake of norepinephrine and cause false negative imaging results: antihypertensives that deplete norepinephrine stores or inhibit reuptake (e.g., reserpine, labetalol), antidepressants that inhibit norepinephrine transporter function (e.g., amitriptyline and derivatives, imipramine and derivatives, selective serotonin reuptake inhibitors), sympathomimetic amines (e.g., phenylephrine, phenylpropanolamine, pseudoephedrine and ephedrine), and cocaine.

Iobenguane i 123 label, warnings and precautions
If the AdreView imaging information is essential for clinical care, consider the withdrawal of the following categories of medications if the withdrawal can be accomplished safely: antihypertensives that deplete norepinephrine stores or inhibit reuptake (e.g., reserpine, labetalol), antidepressants that inhibit norepinephrine transporter function (e.g., amitriptyline and derivatives, imipramine and derivatives, selective serotonin reuptake inhibitors), and sympathomimetic amines (e.g., phenylephrine, phenylpropanolamine, pseudoephedrine and ephedrine).

Source: FDA drug label (AdreView), Medi-Physics Inc., effective January 10, 2024 (SPL set c89d3ecc-4f4c-4566-8808-79152344194d), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

34Amitriptyline generic labelers

0Iobenguane i 123 generic labelers

	Amitriptyline	Iobenguane i 123
Labeled for	Depression	n/a
Boxed warning	Yes	No
Pharmacy cost (NADAC)	$0.03 per tablet 10 mg tablet	n/a
Shortage now	No current entry	No current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?

Amitriptyline: the full record
Iobenguane i 123: the full record
Check more medicines together: up to five at once