What the FDA labels say about taking them together
Amitriptyline and fosamprenavir
Fosamprenavir's FDA label of September 15, 2023 names amitriptyline in its drug interactions section; the amitriptyline label PlainMeds reads does not name fosamprenavir. The fosamprenavir label: “Therapeutic concentration monitoring is recommended for tricyclic antidepressants.”
Check it at the source: the amitriptyline FDA label on DailyMed (effective September 8, 2026, Sun Pharmaceutical Industries, Inc.); the fosamprenavir FDA label on DailyMed (effective September 15, 2023, Mylan Pharmaceuticals Inc.).
What does the amitriptyline label say about fosamprenavir?
Amitriptyline's label (effective September 8, 2026) does not name fosamprenavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amitriptyline Hydrochloride), Sun Pharmaceutical Industries, Inc., effective September 8, 2026 (SPL set 4e520c63-1cf6-40f6-a51c-3f9b0e181342), via openFDA; the full label on DailyMed
What does the fosamprenavir label say about amitriptyline?
Fosamprenavir label, drug interactionsConcomitant Drug Class/Drug Name: Tricyclic antidepressants: Amitriptyline, imipramine; Effect on Concentration of Amprenavir or Concomitant Drug: ↑ Tricyclics; Clinical Comment: Therapeutic concentration monitoring is recommended for tricyclic antidepressants.
Source: FDA drug label (Fosamprenavir Calcium), Mylan Pharmaceuticals Inc., effective September 15, 2023 (SPL set 3a1424d8-844c-4e24-9ebd-b2c2b61b61a3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amitriptyline | Fosamprenavir | |
|---|---|---|
| Labeled for | Depression | HIV |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.03 per tablet 10 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once