What the FDA labels say about taking them together
Amitriptyline and dronabinol
Dronabinol's FDA label of May 6, 2026 names amitriptyline in its warnings and precautions section; the amitriptyline label PlainMeds reads does not name dronabinol. The dronabinol label: “Avoid concomitant use of other drugs that are also associated with similar cardiac effects.”
Check it at the source: the amitriptyline FDA label on DailyMed (effective September 8, 2026, Sun Pharmaceutical Industries, Inc.); the dronabinol FDA label on DailyMed (effective May 6, 2026, Ascend Laboratories, LLC).
What does the amitriptyline label say about dronabinol?
Amitriptyline's label (effective September 8, 2026) does not name dronabinol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amitriptyline Hydrochloride), Sun Pharmaceutical Industries, Inc., effective September 8, 2026 (SPL set 4e520c63-1cf6-40f6-a51c-3f9b0e181342), via openFDA; the full label on DailyMed
What does the dronabinol label say about amitriptyline?
Dronabinol label, warnings and precautionsAvoid concomitant use of other drugs that are also associated with similar cardiac effects (e.g., amphetamines, other sympathomimetic agents, atropine, amoxapine, scopolamine, antihistamines, other anticholinergic agents, amitriptyline, desipramine, other tricyclic antidepressants).
Source: FDA drug label (Dronabinol), NDA018651 (Alkem Labs Ltd), as published by Ascend Laboratories, LLC, effective May 6, 2026 (SPL set adb1801c-0fb5-4e16-b969-1db91230e0b9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amitriptyline | Dronabinol | |
|---|---|---|
| Labeled for | Depression | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.03 per tablet 10 mg tablet | $3.35 per capsule 5 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once