What the FDA labels say about taking them together
Amitriptyline and divalproex
Divalproex's FDA label of March 31, 2026 names amitriptyline in its drug interactions section; the amitriptyline label PlainMeds reads does not name divalproex. The divalproex label: “… a low dose, and titrate to clinically effective dose Dosage adjustment of amitriptyline/nortriptyline, propofol, warfarin, and zidovudine may be necessary if used concomitantly with Depakote Topiramate:”
Check it at the source: the amitriptyline FDA label on DailyMed (effective September 8, 2026, Sun Pharmaceutical Industries, Inc.); the divalproex FDA label on DailyMed (effective March 31, 2026, AbbVie Inc.).
What does the amitriptyline label say about divalproex?
Amitriptyline's label (effective September 8, 2026) does not name divalproex in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amitriptyline Hydrochloride), Sun Pharmaceutical Industries, Inc., effective September 8, 2026 (SPL set 4e520c63-1cf6-40f6-a51c-3f9b0e181342), via openFDA; the full label on DailyMed
What does the divalproex label say about amitriptyline?
Divalproex label, drug interactionsMonitoring of valproate concentrations is recommended ( 7.1 ) Co-administration of valproate can affect the pharmacokinetics of other drugs (e.g., diazepam, ethosuximide, lamotrigine, phenytoin) by inhibiting their metabolism or protein binding displacement ( 7.2 ) Patients stabilized on rufinamide should begin valproate therapy at a low dose, and titrate to clinically effective dose ( 7.2 ) Dosage adjustment of amitriptyline/nortriptyline, propofol, warfarin, and zidovudine may be necessary if used concomitantly with Depakote ( 7.2 ) Topiramate:
Source: FDA drug label (Depakote), AbbVie Inc., effective March 31, 2026 (SPL set 08a65cf4-7749-4ceb-6895-8f4805e2b01f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amitriptyline | Divalproex | |
|---|---|---|
| Labeled for | Depression | Bipolar disorder, Migraine, Seizures and epilepsy |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.03 per tablet 10 mg tablet | $0.194 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once