What the FDA labels say about taking them together
Aminophylline and ketamine
Aminophylline's FDA label of May 22, 2026 names ketamine in its drug interactions section, and ketamine's label names aminophylline too. The aminophylline label: “20% decrease Ketamine Pharmacologic May lower theophylline seizure threshold.”
Check it at the source: the aminophylline FDA label on DailyMed (effective May 22, 2026, Hospira, Inc.); the ketamine FDA label on DailyMed (effective March 27, 2026, Par Health USA, LLC).
What does the aminophylline label say about ketamine?
Aminophylline label, drug interactions20% decrease Ketamine Pharmacologic May lower theophylline seizure threshold.
Source: FDA drug label (Aminophylline), Hospira, Inc., effective May 22, 2026 (SPL set 9a663ef3-881f-48bd-2689-3713b24545c2), via openFDA; the full label on DailyMed
What does the ketamine label say about aminophylline?
Ketamine label, drug interactionsDRUG INTERACTIONS Theophylline or Aminophylline: Do not co-administer with KETALAR as concomitant use may lower the seizure threshold ( 7.1 ).
Ketamine label, warnings and precautionsTheophylline or Aminophylline: Concomitant administration of KETALAR and theophylline or aminophylline may lower the seizure threshold [see Drug Interactions ( 7.1 )].
Source: FDA drug label (Ketalar), Par Health USA, LLC, effective March 27, 2026 (SPL set 14e8f864-8b8a-4e7e-8439-e510d3107063), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aminophylline | Ketamine | |
|---|---|---|
| Labeled for | Asthma | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.556 per mL 500 mg/10 mL vial |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once