What the FDA labels say about taking them together
Aminophylline and erythromycin
Aminophylline's FDA label of May 22, 2026 names erythromycin in its drug interactions section; the erythromycin labels PlainMeds reads (4) do not name aminophylline. The aminophylline label: “Drug: Clarithromycin; Type Of Interaction: Similar to erythromycin.; Effect**: 25% increase”
Check it at the source: the aminophylline FDA label on DailyMed (effective May 22, 2026, Hospira, Inc.); the erythromycin FDA label on DailyMed (effective August 1, 2024, Teva Pharmaceuticals USA, Inc.).
What does the aminophylline label say about erythromycin?
Aminophylline label, drug interactionsDrug: Clarithromycin; Type Of Interaction: Similar to erythromycin.; Effect**: 25% increase
Aminophylline label, warningsAge Neonates (term and premature) Children <1 year Elderly (>60 years) Concurrent Diseases Acute pulmonary edema Congestive heart failure Cor pulmonale Fever; ≥102° for 24 hours or more; or lesser temperature elevations for longer periods Hypothyroidism Liver disease; cirrhosis, acute hepatitis Reduced renal function in infants <3 months of age Sepsis with multi-organ failure Shock Cessation of Smoking Drug Interactions Adding a drug that inhibits theophylline metabolism (e.g., cimetidine, erythromycin, tacrine) or stopping a concurrently administered drug that enhances theophylline metabolism (e.g., carbamazepine, rifampin) (see PRECAUTIONS , Drug Interactions, Table II ).
Source: FDA drug label (Aminophylline), Hospira, Inc., effective May 22, 2026 (SPL set 9a663ef3-881f-48bd-2689-3713b24545c2), via openFDA; the full label on DailyMed
What does the erythromycin label say about aminophylline?
Erythromycin's label (effective August 1, 2024) and its 3 other brand-application labels do not name aminophylline in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Erythromycin), Teva Pharmaceuticals USA, Inc., effective August 1, 2024 (SPL set 75a0bd5a-d09f-483b-bfd8-f8343b149eb2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aminophylline | Erythromycin | |
|---|---|---|
| Labeled for | Asthma | Bacterial infections, Acne |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $1.96 per tablet 250 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once