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What the FDA labels say about taking them together

Aminophylline and disulfiram

Aminophylline's FDA label of May 22, 2026 names disulfiram in its drug interactions section; the disulfiram label PlainMeds reads does not name aminophylline. The aminophylline label: “Disulfiram Decreases theophylline clearance by inhibiting hydroxylation and demethylation.”

Check it at the source: the aminophylline FDA label on DailyMed (effective May 22, 2026, Hospira, Inc.); the disulfiram FDA label on DailyMed (effective August 20, 2024, Sigmapharm Laboratories, LLC).

What does the aminophylline label say about disulfiram?

Aminophylline label, drug interactions

Disulfiram Decreases theophylline clearance by inhibiting hydroxylation and demethylation.

Source: FDA drug label (Aminophylline), Hospira, Inc., effective May 22, 2026 (SPL set 9a663ef3-881f-48bd-2689-3713b24545c2), via openFDA; the full label on DailyMed

What does the disulfiram label say about aminophylline?

Disulfiram's label (effective August 20, 2024) does not name aminophylline in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Disulfiram), Sigmapharm Laboratories, LLC, effective August 20, 2024 (SPL set 40f5497f-fe84-43b2-8ff4-32d59edf3917), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

5Aminophylline generic labelers
5Disulfiram generic labelers
AminophyllineDisulfiram
Labeled forAsthmaAlcohol use disorder
Boxed warningNoYes
Pharmacy cost (NADAC)n/a$1.82 per tablet 250 mg tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?